Vital Surveillances: Temporal and Spatial Trends in HIV Positivity Rate for VCT Clinics — China, 2015–2022

Data on HIV testing and reported HIV cases from VCT clinics were obtained from the China Information System for Disease Control and Prevention. The data were collected annually and included the following variables: 1) geographical location of the VCT clinic, 2) number of HIV tests conducted, and 3) number of newly-reported HIV cases. It is important to highlight that the HIV cases included in the analysis met two simultaneous criteria: they were Chinese cases, and they were reported within the period from January 1, 2015 to December 31, 2022.

Administrative division data were obtained from the National Bureau of Statistics, accessed on September 20, 2023, via the official website ( http://www.stats.gov.cn/sj/tjbz/qhdm/ ). The analytical framework employed spatial units comprising a total of 367 units. These units consisted of 333 municipal-level administrative districts, 4 municipalities directly governed by the central government, and 30 counties under provincial jurisdiction.

The HPR for VCT clinic was calculated using the following formula: $\mathrm{H}\mathrm{P}\mathrm{R}= $ $\dfrac{\mathrm{N}\mathrm{u}\mathrm{m}\mathrm{b}\mathrm{e}\mathrm{r}\;\mathrm{o}\mathrm{f}\;\mathrm{n}\mathrm{e}\mathrm{w}\mathrm{l}\mathrm{y}\;\mathrm{r}\mathrm{e}\mathrm{p}\mathrm{o}\mathrm{r}\mathrm{t}\mathrm{e}\mathrm{d}\;\mathrm{H}\mathrm{I}\mathrm{V}\;\mathrm{c}\mathrm{a}\mathrm{s}\mathrm{e}\mathrm{s}}{\mathrm{N}\mathrm{u}\mathrm{m}\mathrm{b}\mathrm{e}\mathrm{r}\;\mathrm{o}\mathrm{f}\;\mathrm{H}\mathrm{I}\mathrm{V}\;\mathrm{t}\mathrm{e}\mathrm{s}\mathrm{t}\mathrm{s}}\times 100\%$ . The provincial-level administrative divisions (PLADs) with HPR exceeding the median value in 2015 were categorized as high HPR areas. Conversely, the PLADs below this threshold were labeled as low HPR areas. To examine the temporal trends of HPR from 2015 to 2022, we estimated the annual percent change (APC) and the average annual percent change (AAPC), along with their respective 95% confidence intervals (CI), by jointpoint regression. The assessment of spatial correlation in HPR was conducted using the Global Moran’sIstatistic. UnderP<0.05, positive values of Moran’sIindicated a positive spatial correlation. The Moran’sIcloser to 1 signified that neighboring spatial units exhibited greater similarity or clustered distribution. The Moran’sIcloser to 0 indicated a random spatial distribution. Getis-Ord (Gi*) hotspot analysis was used to identify hotspots (Z>1.96) and cold spots (Z<−1.96) of HPR. Statistical analyses were conducted in the R (version 4.1.1; R Core Team and the R Foundation for Statistical Computing, Vienna, Austria), Joinpoint Regression Program (version 4.9.0.1; National Cancer Institute, Bethesda, US), and Geoda (version 1.20.0; University of Chicago, Chicago, US), and all tests were two-tailed with statistical significance atP<0.05.

Between 2015 and 2022, VCT clinics in China offered a total of 22,075,386 HIV tests, which led to the identification of 260,353 newly-reported HIV cases. These newly-reported cases accounted for 25.0% (260,353/1,043,165) of the total number of HIV cases reported in China during the same period (Table 1). The number of HIV tests showed a consistent increase from 2,397,271 in 2015 to 3,088,305 in 2018, representing a significant rise of 22.3%. However, there was a decline in 2019, with 2,797,414 tests performed in 2022, equivalent to 90.5% (2,797,414/3,088,305) of the 2018 level. Regarding newly-reported HIV cases, there was an upward trend from 33,423 cases in 2015 to 37,407 cases in 2019. However, this trend reversed in 2020, resulting in a decrease in the number of newly-reported cases. In 2022, there were 22,954 cases, accounting for 61.3% (22,954/37,407) of the 2019 count.

Overall, the HPR for VCT clinics was 1.18% (260,353/22,075,386) between 2015 and 2022 (Table 1). During this period, there was a significant decline in the HPR (AAPC=−7.5%, 95%CI: −12.6%, −2.2%), dropping from 1.39% in 2015 to 0.82% in 2022, with a reduction of 41.01% (Table 1). The APC of HPR was −3.8% (95%CI: −12.4%, 5.6%) from 2015 to 2019. Following this period, the downward trend accelerated from 2020 to 2022 (APC=−12.2%, 95%CI: −26.2%, −12.2%).

None of the 31 PLADs demonstrated the trend of increase in the HPR between 2015 and 2022, as shown inTable 2. Based on the median HPR value (1.10%) observed in the 31 PLADs in 2015, 16 PLADs were classified as high HPR PLADs (HPR>1.10%), as depicted inFigure 1. The remaining 15 PLADs were categorized as low HPR PLADs (HPR<1.10%), also illustrated inFigure 1. Among the 16 high HPR PLADs, seven PLADs, namely Beijing, Shanghai, Fujian, and others, exhibited a statistically significant downward trend (AAPC<0,P_AAPC<0.05), with Beijing showing the most rapid decline in HPR (AAPC=−12.6%, 95%CI: −18.1%, −6.7%). Conversely, nine PLADs including Sichuan, Chongqing, Guangdong, and others, did not display a notable downward trend in HPR (P_AAPC>0.05). Of the 15 low HPR PLADs, nine, such as Shanxi, Inner Mongolia, Liaoning, and others, showed a downward trend in HPR (AAPC<0,P_AAPC<0.05). Notably, Xizang PLAD experienced the most substantial decline in HPR (AAPC=−25.8%, 95%CI: −38.7%, −10.3%). In contrast, six PLADs including Hebei, Jiangxi, Anhui, and others, showed a decrease in HPR, but the changes were not statistically significant (P_AAPC>0.05).

Figure 1.

Trends in the HPR for VCT clinics from 2015 to 2022, broken down by PLADs. (A) High HPR-decline; (B) High HPR-no decline; (C) Low HPR-decline; and (D) Low HPR-no decline.

Abbreviation: HIV=human immunodeficiency virus; HPR=HIV positivity rate; VCT=voluntary counseling and testing; PLADs=provincial-level administrative divisions.

Between 2015 and 2022, the HPR for 367 study units had no spatial autocorrelation (Z=0.84,P=0.128) only in 2016 (Table 3). There was a decrease in the number of HPR hotspots over these years, declining from 41 in 2015 to 23 in 2022. In general, these HPR hotspots were predominantly concentrated in Yunnan, Sichuan, Guangdong, and Guangxi PLADs. Between 2015 and 2017, the hotspots predominantly appeared in Yunnan, Sichuan, Guangxi, and Guangdong PLADs. From 2018 onward, hotspot numbers decreased in Yunnan and Sichuan PLADs, whereas Xinjiang PLAD noted an increase. Between 2020 and 2022, the hotspots were mainly concentrated in Guangdong and Xinjiang PLADs. However, the distribution of cold spots remained relatively stable, mainly concentrated in the northern China, including Shanxi, Inner Mongolia, Ningxia, Shaanxi, Gansu, and Qinghai PLADs.

This study reveals that the number of HIV tests offered by VCT clinics in China exhibited an increase followed by a decrease between 2015 and 2022, while the HPR for VCT clinics exhibited an overall decrease. In 2012, China released the 12th Five-Year Plan for HIV Prevention and Control, which states that China would expand HIV testing, raise public awareness of HIV testing, and promote active testing (4). Nevertheless, the growth rate in HIV test numbers for VCT clinics has lagged behind that in medical institutions (5). This is mainly because VCT clinics are influenced by the individual initiative of visitors and external factors. Future efforts will likely concentrate on improving the convenience and privacy of VCT services. The number of HIV tests in 2020 and 2022 was significantly lower than in surrounding years, possibly related to the coronavirus disease 2019 (COVID-19) pandemic (6).

The present study observed a higher HPR in VCT clinics compared to medical institutions in a previous study (5). This discrepancy can primarily be attributed to the fact that VCT clinics primarily serve individuals engaged in high-risk sexual behaviors (3). In medical institutions, HIV testing mainly involves mandatory tests associated with surgeries and invasive procedures, and provider-initiated testing and counseling (PITC) services (5). It is important to note that the majority of individuals undergoing HIV tests in medical institutions belong to the general population, which typically exhibits a lower likelihood of HIV infection. Consequently, the efficiency of HIV testing in medical institutions is lower. Remarkably, VCT clinics identified 25.0% of all HIV cases, despite VCT testing constituting only 1.2% of the total annual HIV tests conducted in China (7). This underscores the critical role that VCT clinics play in identifying HIV cases in the country. Therefore, it is essential for VCT clinics to continue fulfilling this pivotal role, not only in terms of HIV case detection but also in promoting HIV testing awareness through online and offline combination.

Another significant finding is the overall decline in HPR. More than half of the 31 PLADs have shown a decreasing trend in HPR between 2015 and 2022. It may suggest that progress has been made in mitigating HIV epidemic among key populations through the implementation of the 13th Five-Year Plan for HIV prevention and control and the Implementation Program for Controlling the Spread of HIV (2019–2022) (8). In recent years, the Chinese government has consistently emphasized the importance of regular HIV testing and testing frequency among high-risk populations. Notable improvements in HIV testing rates have been observed among men who have sex with men (MSM) through referrals for testing by non-governmental organizations and educational outreach on social networking apps (9). The decline in HPR since 2020 can, in part, be attributed to the impact of the COVID-19 pandemic (10). Research has shown that concerns related to COVID-19 and the non-pharmacological interventions implemented by the government have reduced the likelihood of engaging in high-risk sexual behavior or meeting new sexual partners (11). Consequently, this reduction in high-risk behavior may have indirectly contributed to both a lower risk of HIV infection and a decrease in the demand for HIV testing, resulting in the decline in HPR. Moving forward, it is crucial to maintain active HIV surveillance and implement targeted interventions to prevent any resurgence of the HIV epidemic among key populations. PLADs that have not experienced a significant decline in HPR should consider exploring innovative operational approaches, such as integrating passive counseling and testing services with proactive outreach for HIV prevention.

Between 2015 and 2022, the distribution of hotspots and cold spots for HPR in China corresponded to the spatial distribution characteristics of the HIV epidemic (12). PLADs such as Sichuan, Yunnan, and Guangxi have been particularly affected by the HIV epidemic in China (13). As of 2017, the Chinese government has been implementing comprehensive HIV testing measures that cover the entire population in high HIV prevalence regions located in southwestern China. It is possible that this policy has indirectly resulted in a decrease in the proportion of HIV cases reported by VCT clinics in that area (14). Starting in 2018, new hotspots have appeared in Guangdong, Guangxi, and Xinjiang, consistent with previous research findings (15). These developments underline the importance of closely monitoring the HIV epidemic in these current hotspots and implementing targeted HIV surveillance and intervention activities.

This study had several limitations. First, the data on HIV tests for VCT clinics were reported as test counts rather than individual-level data. The characteristics of people receiving HIV testing in VCT clinics may vary in different years. Consequently, the proportion of individuals who undergo repeat testing at VCT clinics each year is unknown. This knowledge gap may result in an underestimation of the HPR. Second, the number of HIV tests conducted and newly-reported HIV cases are influenced by factors such as testing willingness, testing conditions, and accessibility. These factors may not fully capture the true HIV prevalence within key populations. Thus, the data may be subject to bias and may not provide a comprehensive depiction of the actual situation.ta may be subject to bias and may not provide a comprehensive depiction of the actual situation.

In conclusion, VCT clinics in China have played a significant role in detecting HIV cases. The decreasing HPR observed in these clinics may suggests that China has made notable strides in curbing HIV prevalence among high-risk populations. It is crucial to further improve the utilization of VCT clinics for the identification of HIV cases. Moving forward, it is vital to explore novel models for VCT services, such as integrating passive testing with proactive outreach services, to enhance their effectiveness.

No conflicts of interest.

The provincial and local CDCs.