http://weekly.chinacdc.cn/ China CDC Weekly cdcwjournal@163.com cdcwjournal@163.com en cdcwjournal@163.com 2096-7071 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.180?pageType=en Naiying Mao, Zhen Zhu, Shuangli Zhu, Deshan Yu, Jun Xu, Aili Cui, Lei Cao, Jinyuan Guo, Huiling Wang, Dongyan Wang, Dongmei Yan, Yang Song, Qian Yang, Zhongyi Jiang, Hui Zhang, Chang Shu, Ming Yang, Yanhai Wang, Jinbo Xiao, Zhenzhi Han, Yong Zhang, Yan Zhang, Wenbo Xu <sec< <b< <b<What is already known about this topic?</b< </b< <p<Coronavirus disease 2019 (COVID-19) has become a global pandemic, while the profile of antibody response against the COVID-19 virus has not been well clarified.</p< </sec<<sec< <b< <b<What is added by this report?</b< </b< <p<In this study, 210 serum samples from 160 confirmed COVID-19 cases with different disease severities were recruited. The IgM, IgA, IgG, and neutralizing antibodies (NAb) against COVID-19 virus were determined. Our findings indicated that four antibodies could be detectable at low levels within 2 weeks of disease onset, then rapidly increasing and peaking from the 3<sup<rd</sup< to 5<sup<th</sup< Weeks. NAb decreased between 5<sup<th</sup< and 9<sup<th</sup< Weeks, and a higher IgM/IgA level was observed in the groups with mild/moderate severity within 2 weeks (<i<p</i<<0.05), while all 4 types of antibodies were higher in the group with severe/critical severity after 4 weeks (<i<p</i<<0.05).</p< </sec<<sec< <b< <b<What are the implications for public health practice?</b< </b< <p<Our study on the dynamics of serological antibody responses against COVID-19 virus among COVID-19 patients complements the recognition regarding the humoral immune response to COVID-19 virus infection. The findings will help in the interpretation of antibody detection results for COVID-19 patients and be beneficial for the evaluation of vaccination effects.</p< </sec< China CDC Weekly. 2020 2(34): 645-650. Naiying Mao, Zhen Zhu, Shuangli Zhu, Deshan Yu, Jun Xu, Aili Cui, Lei Cao, Jinyuan Guo, Huiling Wang, Dongyan Wang, Dongmei Yan, Yang Song, Qian Yang, Zhongyi Jiang, Hui Zhang, Chang Shu, Ming Yang, Yanhai Wang, Jinbo Xiao, Zhenzhi Han, Yong Zhang, Yan Zhang, Wenbo Xu <sec< <b< <b<What is already known about this topic?</b< </b< <p<Coronavirus disease 2019 (COVID-19) has become a global pandemic, while the profile of antibody response against the COVID-19 virus has not been well clarified.</p< </sec<<sec< <b< <b<What is added by this report?</b< </b< <p<In this study, 210 serum samples from 160 confirmed COVID-19 cases with different disease severities were recruited. The IgM, IgA, IgG, and neutralizing antibodies (NAb) against COVID-19 virus were determined. Our findings indicated that four antibodies could be detectable at low levels within 2 weeks of disease onset, then rapidly increasing and peaking from the 3<sup<rd</sup< to 5<sup<th</sup< Weeks. NAb decreased between 5<sup<th</sup< and 9<sup<th</sup< Weeks, and a higher IgM/IgA level was observed in the groups with mild/moderate severity within 2 weeks (<i<p</i<<0.05), while all 4 types of antibodies were higher in the group with severe/critical severity after 4 weeks (<i<p</i<<0.05).</p< </sec<<sec< <b< <b<What are the implications for public health practice?</b< </b< <p<Our study on the dynamics of serological antibody responses against COVID-19 virus among COVID-19 patients complements the recognition regarding the humoral immune response to COVID-19 virus infection. The findings will help in the interpretation of antibody detection results for COVID-19 patients and be beneficial for the evaluation of vaccination effects.</p< </sec< China CDC Weekly. 2020 2(34): 645-650. Antibody Response to COVID-19 Virus — Heilongjiang Province and Gansu Province, China, 2020 Naiying Mao, Zhen Zhu, Shuangli Zhu, Deshan Yu, Jun Xu, Aili Cui, Lei Cao, Jinyuan Guo, Huiling Wang, Dongyan Wang, Dongmei Yan, Yang Song, Qian Yang, Zhongyi Jiang, Hui Zhang, Chang Shu, Ming Yang, Yanhai Wang, Jinbo Xiao, Zhenzhi Han, Yong Zhang, Yan Zhang, Wenbo Xu 2020-08-21 Personal use only, all commercial or other reuse prohibited China CDC Weekly. 2020 2(34): 645-650. article doi:10.46234/ccdcw2020.180 10.46234/ccdcw2020.180 China CDC Weekly 2 34 2020-08-21 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.180?pageType=en 645 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.181?pageType=en Qinglong Zhao, Meng Yang, Yao Wang, Laishun Yao, Jianguo Qiao, Zhiyong Cheng, Hanyin Liu, Xingchun Liu, Yuanzhao Zhu, Zeyu Zhao, Jia Rui, Tianmu Chen <sec< <b< <b<What is already known about this topic?</b< </b< <p<COVID-19 has a high transmissibility calculated by mathematical model. The dynamics of the disease and the effectiveness of intervention to control the transmission remain unclear in Jilin Province, China.</p<</sec<<sec< <b< <b<What is added by this report?</b< </b< <p<This is the first study to report the dynamic characteristics and to quantify the effectiveness of interventions implemented in the second outbreak of COVID-19 in Jilin Province, China. The effective reproduction number of the disease before and after May 10 was 4.00 and <i<p</i<<0.01, respectively. The combined interventions reduced the transmissibility of COVID-19 by 99% and the number of cases by 98.36%.</p<</sec<<sec< <b< <b<What are the implications for public health practice?</b< </b< <p<The findings of this study would add data on the transmission of COVID-19 and provide evidence to prepare the second outbreak transmission of the disease in other areas of China even in many other countries.</p<</sec< China CDC Weekly. 2020 2(34): 651-654. Qinglong Zhao, Meng Yang, Yao Wang, Laishun Yao, Jianguo Qiao, Zhiyong Cheng, Hanyin Liu, Xingchun Liu, Yuanzhao Zhu, Zeyu Zhao, Jia Rui, Tianmu Chen <sec< <b< <b<What is already known about this topic?</b< </b< <p<COVID-19 has a high transmissibility calculated by mathematical model. The dynamics of the disease and the effectiveness of intervention to control the transmission remain unclear in Jilin Province, China.</p<</sec<<sec< <b< <b<What is added by this report?</b< </b< <p<This is the first study to report the dynamic characteristics and to quantify the effectiveness of interventions implemented in the second outbreak of COVID-19 in Jilin Province, China. The effective reproduction number of the disease before and after May 10 was 4.00 and <i<p</i<<0.01, respectively. The combined interventions reduced the transmissibility of COVID-19 by 99% and the number of cases by 98.36%.</p<</sec<<sec< <b< <b<What are the implications for public health practice?</b< </b< <p<The findings of this study would add data on the transmission of COVID-19 and provide evidence to prepare the second outbreak transmission of the disease in other areas of China even in many other countries.</p<</sec< China CDC Weekly. 2020 2(34): 651-654. Effectiveness of Interventions to Control Transmission of Reemergent Cases of COVID-19 — Jilin Province, China, 2020 Qinglong Zhao, Meng Yang, Yao Wang, Laishun Yao, Jianguo Qiao, Zhiyong Cheng, Hanyin Liu, Xingchun Liu, Yuanzhao Zhu, Zeyu Zhao, Jia Rui, Tianmu Chen 2020-08-21 Personal use only, all commercial or other reuse prohibited China CDC Weekly. 2020 2(34): 651-654. article doi:10.46234/ccdcw2020.181 10.46234/ccdcw2020.181 China CDC Weekly 2 34 2020-08-21 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.181?pageType=en 651 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.162?pageType=en Hualei Xin, Jiwei Liang, Fachun Jiang China CDC Weekly. 2020 2(34): 655-657. Hualei Xin, Jiwei Liang, Fachun Jiang China CDC Weekly. 2020 2(34): 655-657. A Hospital Superspreading Event of COVID-19 — Qingdao City, Shandong Province, China, 2020 Hualei Xin, Jiwei Liang, Fachun Jiang 2020-08-21 Personal use only, all commercial or other reuse prohibited China CDC Weekly. 2020 2(34): 655-657. article doi:10.46234/ccdcw2020.162 10.46234/ccdcw2020.162 China CDC Weekly 2 34 2020-08-21 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.162?pageType=en 655 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.182?pageType=en Xiang Zhao, Lingling Mao, Jianqun Zhang, Yong Zhang, Yang Song, Zhijian Bo, Hong Wang, Ji Wang, Cao Chen, Jinbo Xiao, Tianjiao Ji, Qian Yang, Wenbo Xu, Dayan Wang, Wenqing Yao China CDC Weekly. 2020 2(34): 658-660. Xiang Zhao, Lingling Mao, Jianqun Zhang, Yong Zhang, Yang Song, Zhijian Bo, Hong Wang, Ji Wang, Cao Chen, Jinbo Xiao, Tianjiao Ji, Qian Yang, Wenbo Xu, Dayan Wang, Wenqing Yao China CDC Weekly. 2020 2(34): 658-660. Reemergent Cases of COVID-19 — Dalian City, Liaoning Province, China, July 22, 2020 Xiang Zhao, Lingling Mao, Jianqun Zhang, Yong Zhang, Yang Song, Zhijian Bo, Hong Wang, Ji Wang, Cao Chen, Jinbo Xiao, Tianjiao Ji, Qian Yang, Wenbo Xu, Dayan Wang, Wenqing Yao 2020-08-21 Personal use only, all commercial or other reuse prohibited China CDC Weekly. 2020 2(34): 658-660. article doi:10.46234/ccdcw2020.182 10.46234/ccdcw2020.182 China CDC Weekly 2 34 2020-08-21 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.182?pageType=en 658 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.169?pageType=en Wenzhou Yu, Yuanqiu Li, Jing Wu, Fuzhen Wang, Ning Wen, Lance Rodewald, Lixin Hao, Yixing Li, Hui Zheng, Keli Li, Chao Ma, Dan Wu, Lei Cao, Lingsheng Cao, Jiakai Ye, Yanmin Liu, Guomin Zhang, Wen Du, Zhijie An, Huaqing Wang, Zundong Yin China CDC Weekly. 2020 2(34): 661-665. Wenzhou Yu, Yuanqiu Li, Jing Wu, Fuzhen Wang, Ning Wen, Lance Rodewald, Lixin Hao, Yixing Li, Hui Zheng, Keli Li, Chao Ma, Dan Wu, Lei Cao, Lingsheng Cao, Jiakai Ye, Yanmin Liu, Guomin Zhang, Wen Du, Zhijie An, Huaqing Wang, Zundong Yin China CDC Weekly. 2020 2(34): 661-665. Vaccination Guidelines During and After the COVID-19 Epidemic in China Wenzhou Yu, Yuanqiu Li, Jing Wu, Fuzhen Wang, Ning Wen, Lance Rodewald, Lixin Hao, Yixing Li, Hui Zheng, Keli Li, Chao Ma, Dan Wu, Lei Cao, Lingsheng Cao, Jiakai Ye, Yanmin Liu, Guomin Zhang, Wen Du, Zhijie An, Huaqing Wang, Zundong Yin 2020-08-21 Personal use only, all commercial or other reuse prohibited China CDC Weekly. 2020 2(34): 661-665. article doi:10.46234/ccdcw2020.169 10.46234/ccdcw2020.169 China CDC Weekly 2 34 2020-08-21 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.169?pageType=en 661 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.183?pageType=en Qingyun Sun, Xiaofeng Yan, Cheng Chen, Xuemei Jiang, Jun Cheng China CDC Weekly. 2020 2(34): 666-668. Qingyun Sun, Xiaofeng Yan, Cheng Chen, Xuemei Jiang, Jun Cheng China CDC Weekly. 2020 2(34): 666-668. Tuberculosis Infection Control Project Management Experience and Its Application in COVID-19 Response Qingyun Sun, Xiaofeng Yan, Cheng Chen, Xuemei Jiang, Jun Cheng 2020-08-21 Personal use only, all commercial or other reuse prohibited China CDC Weekly. 2020 2(34): 666-668. article doi:10.46234/ccdcw2020.183 10.46234/ccdcw2020.183 China CDC Weekly 2 34 2020-08-21 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.183?pageType=en 666 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.175?pageType=en Peter Hao, Ying Zhang, Zhenjun Li, Jingjing Xi, Feng Tan China CDC Weekly. 2020 2(34): 669-670. Peter Hao, Ying Zhang, Zhenjun Li, Jingjing Xi, Feng Tan China CDC Weekly. 2020 2(34): 669-670. Zunyou Wu, China CDC’s Chief Expert of Epidemiology Peter Hao, Ying Zhang, Zhenjun Li, Jingjing Xi, Feng Tan 2020-08-21 Personal use only, all commercial or other reuse prohibited China CDC Weekly. 2020 2(34): 669-670. article doi:10.46234/ccdcw2020.175 10.46234/ccdcw2020.175 China CDC Weekly 2 34 2020-08-21 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.175?pageType=en 669

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