http://weekly.chinacdc.cn/ China CDC Weekly cdcwjournal@163.com cdcwjournal@163.com en cdcwjournal@163.com 2096-7071 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.044?pageType=en Fengfeng Liu, Minrui Ren, Shumin Chen, Taoran Nie, Jinzhao Cui, Lu Ran, Zhongjie Li, Zhaorui Chang <sec< <b< <b<What is already known about this topic?</b< </b< <p<Enterovirus 71 (EV-A71) is the main causative pathogen for severe and fatal patients with Hand, Foot, and Mouth Disease (HFMD) in mainland China from 2008 to 2017. Non-EV-A71 and non-CV-A16 (other enterovirus) serotypes were the major causative-serotypes for mild HFMD in years of 2013, 2015, and 2017.</p<</sec<<sec< <b< <b<What is added by this report?</b< </b< <p<In 2018, other enterovirus serotypes replaced EV-A71 for the first time as the major cause of severe HFMD with a proportion of 70.7%. However, at the national level, only a small proportion of the other enterovirus serotypes were further identified as CV-A6 and CV-A10.</p<</sec<<sec< <b< <b<What are the limitations for public health practice?</b< </b< <p<Further identification of other enterovirus serotypes is highly recommended for provincial CDCs, especially for severe HFMD. Studies contributing to a multivalent vaccine for HFMD should be prioritized.</p<</sec< China CDC Weekly. 2020 2(11): 167-171. Fengfeng Liu, Minrui Ren, Shumin Chen, Taoran Nie, Jinzhao Cui, Lu Ran, Zhongjie Li, Zhaorui Chang <sec< <b< <b<What is already known about this topic?</b< </b< <p<Enterovirus 71 (EV-A71) is the main causative pathogen for severe and fatal patients with Hand, Foot, and Mouth Disease (HFMD) in mainland China from 2008 to 2017. Non-EV-A71 and non-CV-A16 (other enterovirus) serotypes were the major causative-serotypes for mild HFMD in years of 2013, 2015, and 2017.</p<</sec<<sec< <b< <b<What is added by this report?</b< </b< <p<In 2018, other enterovirus serotypes replaced EV-A71 for the first time as the major cause of severe HFMD with a proportion of 70.7%. However, at the national level, only a small proportion of the other enterovirus serotypes were further identified as CV-A6 and CV-A10.</p<</sec<<sec< <b< <b<What are the limitations for public health practice?</b< </b< <p<Further identification of other enterovirus serotypes is highly recommended for provincial CDCs, especially for severe HFMD. Studies contributing to a multivalent vaccine for HFMD should be prioritized.</p<</sec< China CDC Weekly. 2020 2(11): 167-171. Pathogen Spectrum of Hand, Foot, and Mouth Disease Based on Laboratory Surveillance — China, 2018 Fengfeng Liu, Minrui Ren, Shumin Chen, Taoran Nie, Jinzhao Cui, Lu Ran, Zhongjie Li, Zhaorui Chang 2020-03-01 Personal use only, all commercial or other reuse prohibited China CDC Weekly. 2020 2(11): 167-171. article doi:10.46234/ccdcw2020.044 10.46234/ccdcw2020.044 China CDC Weekly 2 11 2020-03-01 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.044?pageType=en 167 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.045?pageType=en Jiushun Zhou, Ning Wen, Yong Zhang, Qi Qi, Chunxiang Fan, Dongmei Yan, Xiaoping Zhu, Lixin Hao, Shuangli Zhu, Yu Liu, Xiaozhen Ma, Chao Ma, Lei Nan, Yong Chen, Qianli Ma, Cheng Wang, Kun Deng, Lei Cao, Ge Shao, Xianxiang Ding, Hong Yang, Zhijie An, Lance E. Rodewald, Aiqiang Xu, Huaqing Wang, Zijian Feng, Zundong Yin, Xianping Wu, Wenbo Xu <sec< <b< <b<What is already known about this topic?</b< </b< <p<After the type 2 strain of the live, attenuated poliovirus vaccine was withdrawn globally in 2016, any identification of a type 2 poliovirus is a Public Health Emergency of International Concern. A vaccine-derived type 2 poliovirus (VDPV2) was identified in Sichuan, prompting an urgent, comprehensive investigation and response.</p<</sec<<sec< <b< <b<What is added by this report?</b< </b< <p<Type 2 monovalent, live, attenuated oral poliovirus vaccine (mOPV2) is being used to respond to the numerous VDPV2 outbreaks seen around the world. In contrast, the response in Sichuan used Sabin strain inactivated poliovirus (sIPV) to stop circulation of the VDPV2. In the 6 months following the vaccination response, there have been no VDPV2s detected in Sichuan, despite extensive search.</p<</sec<<sec< <b< <b<What are the implications for public health practices?</b< </b< <p<Further search for the VDPV2 must continue in order to determine whether transmission has been stopped. The ongoing investigation and response to the Sichuan VDPV2 is providing evidence to the Global Polio Eradication Initiative on managing VDPV2 outbreaks.</p<</sec< China CDC Weekly. 2020 2(11): 172-175. Jiushun Zhou, Ning Wen, Yong Zhang, Qi Qi, Chunxiang Fan, Dongmei Yan, Xiaoping Zhu, Lixin Hao, Shuangli Zhu, Yu Liu, Xiaozhen Ma, Chao Ma, Lei Nan, Yong Chen, Qianli Ma, Cheng Wang, Kun Deng, Lei Cao, Ge Shao, Xianxiang Ding, Hong Yang, Zhijie An, Lance E. Rodewald, Aiqiang Xu, Huaqing Wang, Zijian Feng, Zundong Yin, Xianping Wu, Wenbo Xu <sec< <b< <b<What is already known about this topic?</b< </b< <p<After the type 2 strain of the live, attenuated poliovirus vaccine was withdrawn globally in 2016, any identification of a type 2 poliovirus is a Public Health Emergency of International Concern. A vaccine-derived type 2 poliovirus (VDPV2) was identified in Sichuan, prompting an urgent, comprehensive investigation and response.</p<</sec<<sec< <b< <b<What is added by this report?</b< </b< <p<Type 2 monovalent, live, attenuated oral poliovirus vaccine (mOPV2) is being used to respond to the numerous VDPV2 outbreaks seen around the world. In contrast, the response in Sichuan used Sabin strain inactivated poliovirus (sIPV) to stop circulation of the VDPV2. In the 6 months following the vaccination response, there have been no VDPV2s detected in Sichuan, despite extensive search.</p<</sec<<sec< <b< <b<What are the implications for public health practices?</b< </b< <p<Further search for the VDPV2 must continue in order to determine whether transmission has been stopped. The ongoing investigation and response to the Sichuan VDPV2 is providing evidence to the Global Polio Eradication Initiative on managing VDPV2 outbreaks.</p<</sec< China CDC Weekly. 2020 2(11): 172-175. Detection and Initial Response to a Type 2 Vaccine-Derived Poliovirus — Sichuan Province, China, 2019 Jiushun Zhou, Ning Wen, Yong Zhang, Qi Qi, Chunxiang Fan, Dongmei Yan, Xiaoping Zhu, Lixin Hao, Shuangli Zhu, Yu Liu, Xiaozhen Ma, Chao Ma, Lei Nan, Yong Chen, Qianli Ma, Cheng Wang, Kun Deng, Lei Cao, Ge Shao, Xianxiang Ding, Hong Yang, Zhijie An, Lance E. Rodewald, Aiqiang Xu, Huaqing Wang, Zijian Feng, Zundong Yin, Xianping Wu, Wenbo Xu 2020-03-01 Personal use only, all commercial or other reuse prohibited China CDC Weekly. 2020 2(11): 172-175. article doi:10.46234/ccdcw2020.045 10.46234/ccdcw2020.045 China CDC Weekly 2 11 2020-03-01 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.045?pageType=en 172 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.046?pageType=en Huaqing Wang China CDC Weekly. 2020 2(11): 176-179. Huaqing Wang China CDC Weekly. 2020 2(11): 176-179. Why Have cVDPV2 Outbreaks Increased Globally After the Polio Immunization Strategy Switch: Challenges for the Polio Eradication Endgame Huaqing Wang 2020-03-01 Personal use only, all commercial or other reuse prohibited China CDC Weekly. 2020 2(11): 176-179. article doi:10.46234/ccdcw2020.046 10.46234/ccdcw2020.046 China CDC Weekly 2 11 2020-03-01 http://weekly.chinacdc.cn/article/doi/10.46234/ccdcw2020.046?pageType=en 176

map